The drug should not be combined with other ergot derivatives. Dopamine antagonists such as antipsychotics and metoclopramide counteract some effects of cabergoline. The use of antihypertensive drugs should be intensively monitored because excessive hypotension may result from the combination. Cabergoline, sold under the brand name Dostinex among others, is a dopaminergic medication used in the treatment of high prolactin levels, prolactinomas, Parkinson’s disease, and for other indications. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.
- The weekly dose may be given as a single administration or divided into multiple administrations according to patient tolerability.
- Women who wish to become pregnant should conceive at least 1 month after cessation of treatment.
- Information may be obtained if you have access to ToxBase the primary clinical toxicology database of the National Poisons Information Service.
The recommended therapeutic dosage is 2 mg to 3 mg/day for patients with signs and symptoms of Parkinson’s disease. There were maternotoxic effects but no teratogenic effects in mice given cabergoline at doses up to 8 mg/kg/day (approximately 55 times the maximum recommended human dose) during the period of organogenesis. Clinical diagnostic monitoring for development of fibrotic disorders, as appropriate, is essential. Before administration of cabergoline, pregnancy should be excluded.
Cabergoline is used to treat a hormone imbalance in which there is too much prolactin in the blood (also called hyperprolactinemia).
What other drugs will affect cabergoline?
Using https://ppsemployment.com/2022/12/02/the-truth-about-tamoxifen-separating-fact-from/ with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Your blood will need to be tested on a regular basis to measure your prolactin levels.
Important information about all medicines
Cabergoline should not be co-administered with anti-psychotic medications or administered to women with a history of puerperal psychosis. If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist. Initial doses higher than 1.0 mg may produce orthostatic hypotension.